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Robinson et al., preprint, DOI: Interestingly, gravin was previously shown to play a role in β 2 -AR desensitization, sequestration, and resensitization, as agonist stimulation of the β 2 -AR increased interaction between the receptor-gravin complex and protein kinases A and C, GRK2, β -Arr, and clathrin (Bagchi et al., 2018)
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Epinephrine exerts α-adrenergic vasoconstrictive effects , increasing aortic diastolic pressure and coronary perfusion during cardiopulmonary resuscitation, and β-adrenergic effects , increasing heart rate and myocardial contractility to facilitate return of spontaneous circulation (ROSC)
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