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This work was supported by the NIH (R01CA234245 to C.M.M., NIDDK MICROMouse Funding DK076169 to M.K.H., and R01AG065993 to A.C.), a Camille and Henry Dreyfus Teacher–Scholar Award (to C.M.M.), Lowy Medical Research Institute (to C.M.M.) and the American Heart Association (18CDA34110292 to A.C.)

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Discontinuation because of adverse events remained low at 5.9%