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Key safety indicators meet specification, including total heavy metals ≤10 ppm, Pb ≤2 ppm, Hg ≤0.5 ppm, Cd ≤1 ppm, and As ≤3 ppm, with microbiological limits controlled at total plate count ≤1000 cfu/g, yeast and mold ≤100 cfu/g, and E

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Thus, in response to further oxidative insult, the over-activated glial cells, namely microglia, release pro-inflammatory molecules such as tumor necrosis factor alpha (TNF-α), nitric oxide synthase (NOS), and cyclooxygenase-2 (COX-2) [79,80,83,84,85]