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Intranasal drug delivery Intranasal drug delivery is a method of delivering drugs directly to the brain, bypassing the BBB, which avoids the adverse effects that occur when drugs are administered to the brain by other routes and improves patient compliance

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CBD is a non-competitive negative allosteric modulator of the cannabinoid receptor 1 (CB1), an endocannabinoid receptor, in the hippocampus, basal ganglia, basolateral amygdala, hypothalamus, and cerebellum [82]