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Discussion We have reviewed a growing body of preclinical and clinical studies conducted over the past two decades that have examined the development and efficacy of IN CNS therapeutics

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The enzyme is translated as a single polypeptide chain and autocleaves into two subunits that remain noncovalently bound to each other (Kinlough et al., 2005, Nash and Tate, 1982, West and Hanigan, 2010)