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In the TCGA database, the top-ranked hypermethylated gene with accompanying mRNA downregulation in patients with ccRCC was UQCRH , which encodes the mitochondrial complex III component ubiquinol cytochrome c reductase hinge protein 157, 158

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To analyze the selection pressure among the duplicated gene pairs, the ratio of nonsynonymous (Ka) to synonymous (Ks) values were calculated which showed that all of the duplicated genes were negatively selected