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Important limitations include: Limited human studies Small or absent fibromyalgia-specific trials Uncertain long-term safety Variable product quality Different formulations and administration routes Lack of standardized dosing Possible immune reactions or impurities Difficulty separating treatment effects from other therapies Patients should not interpret animal or laboratory findings as proof of pain relief in humans

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Furthermore, this particular beneficial effect may be competing with the Virchow's triad situation that is commonly presented [ i.e