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Redox proteomics: understanding oxidative stress in the progression of age-related neurodegenerative disorders

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Nrf2 can be phosphorylated by several kinases, such as PI3K, protein kinase C (PKC), c-Jun N-terminal kinase (JNK), and extracellular signal-regulated kinases (ERKs), inducing its dissociation from Keap1 and its translocation to the nucleus [71]