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The transcription factor (TF) Srebf1 (SREBP-1c) plays a central role in lipogenesis, and it is activated by insulin, glucose, or fatty acids, with its expression level maintained by itself as an autoregulatory feed-forward loop during lipogenesis (25, 26)

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Vocal noduli, together with vocal polyps, are caused by extensive vocal abuse (shouting, talking loudly for prolonged periods) and are routinely treated surgically [2]