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The Butterfield laboratory, in collaboration with Cotman and Head, confirmed the elevated OS in aged beagle dogs and confirmed that a diet enriched with antioxidant-rich food, coupled with a program of behavioral enrichment [to make new synaptic connections], decreased AD-like neuropathology and, further, led to decreased oxidative damage to specific brain proteins identified by redox proteomics in brains of 15-yr-old dogs (189)