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While the notion of ROS signaling has traditionally been more readily accepted within the plant-pathogen field, many researchers working on metabolic ROS cling, somewhat tenaciously, perhaps, to notions of indiscriminate “damage” as the main phenomenon through which these compounds produce their physiological effects (Møller et al., 2007)

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Proton pump inhibitor (PPI) users : Long-term acid suppression decreases protein-bound B12 release