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Among them, resveratrol, a polyphenol commonly found in grapes and red wine, was the first SIRT1 activator identified in 2003

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The NLRP3 inflammasome is a cytosolic multiprotein complex activated by pathogen- or damage-associated molecular patterns (PAMPs/DAMPs), resulting in caspase-1 activation, maturation of IL-1β and IL-18, and pyroptosis through gasdermin D cleavage (107–111)