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This triggers inflammasome activation and an innate immune response.64 It is therefore possible that genetic susceptibility to APAP overdose could be determined by the ability of an individual to form the toxic imine metabolite determined by genotype for certain drug metabolism genes but also genotype for genes affecting the ability of cells to respond to oxidative stress, the innate immune system generally, and damage repair

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Cohort studies on high altitude illness populations play a vital role in etiological and epidemiological research, continually enriching and deepening our understanding of physiological and pathological changes in humans under high-altitude conditions