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Another study showed that propiophenone derivatives are possibly transformed into Michael acceptors, which most likely inhibit DNMT3A by forming a covalent bond with the catalytic cysteine of the enzyme ( 62 ), an oxazoline DNMTi, had potent inhibitory activity against DNMT1 (IC 50 = 150 μM) (Figure 10) and also exhibited a dose-dependent anti-proliferative effect against HCT116 human colon carcinoma cells