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Supporting the essential role of Ca 2+ signaling in T cell biology, the Ca 2+ regulated protein phosphatase calcineurin is a key target of pharmacologic inhibition for preventing allograft rejection and for autoimmune therapy
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ROS also activate Src kinase, which subsequently activates phospholipase C, leading to the hydrolysis of phosphatidylinositol 4,5-bisphosphate and the generation of inositol triphosphate (IP3) and diacylglycerol (DAG) (74)
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