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CIH induces PD-L1 upregulation in monocytes from healthy volunteers, while enhancing PD-1 expression on CD8 + T cells and recruiting myeloid-derived suppressor cells (MDSCs) to establish an immunosuppressive network ( Based on the PD-1/PD-L1 pathway’s core role, PD-1/PD-L1 inhibitors are established as a key therapeutic strategy for lung cancer—they block PD-1/PD-L1 binding, restore T cell recognition and tumor cell clearance, delay tumor growth, and prolong survival
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5 The current study is aimed to continue the previous study to investigate whether curcumin may play a role in tendon stem cells contributing to the recovery of tendon function