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Accordingly, extensive studies in the mouse models of CBS deficiency showed mice with homozygotic CBS deletion (CBS-/-) died within 4 weeks after birth due to severe hepatic dysfunction and exhibited extremely high levels of circulating Hcy (reviewed in [26, 27])
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Although individuals who have not yet been vaccinated are at the highest risk for serious illness from COVID-19, those who were vaccinated more than six months ago, or those who fall into a high-risk category, are also at an increased risk, as antibodies from their initial vaccine begin to wane