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This idea is consistent with the known depletion of cBMAT, which primarily occurs in three settings: during severe anorexia, in the end stages of starvation and in pathologic conditions associated with severe wasting and cachexia 17,18,19

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Transcription activator factor 3 (ATF3) could activate the unfolded protein response (UPR) and promote the formation of ADM in pancreatitis in the presence of KRAS G12D (Azizi et al., 2021)