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Esculetin as a coumarin compound in various plants exhibited strong anti-inflammatory effect, reduced the levels of IL-1β, IL-6, and TNF-α in serum and hippocampus, and down-regulated the hippocampal expression of iNOS and COX-2 in LPS-depressed mice (91)

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In a randomized controlled clinical trial, supplementation with 200 mg/day of CoQ10 from 20 weeks of gestation until delivery significantly reduced the incidence of PE in high-risk pregnant women 41