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In fact, RelA, the synthase that synthesizes (p)ppGpp binds to the ribosome directly, particularly those ribosomes that harbor an unacylated tRNA in the A-site, which occurs as a result of amino acid starvation, further stimulating the cellular production of (p)ppGpp
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Dihexa works by binding to the HGF receptor c-Met on hippocampal neurons, activating intracellular signaling pathways that increase synaptogenesis, dendritic spine density, and NMDA receptor expression