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Analysis of gene expression changes of drug metabolizing enzymes in the livers of F344 rats following oral treatment with kava extract
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Ultrastructural observations of cardiomyocytes have also shown the presence of iron-laden lysosomes, which rupture into the cell sap, causing intracellular damage including large cytoplasmic vacuoles, swollen mitochondria with no iron deposits but with loss of their cristae, substantial loss of myofilaments, an increase in the electron density of nuclei, and also increased amounts of heterochromatin (Figure 3b,c) [86]