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Cagrilintide — the Phase 2 monotherapy trial studied once-weekly doses of 0.3, 0.6, 1.2, 2.4, and 4.5 mg with a dose-escalation period

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Treatment of 4.2 –/– mice with mitapivat significantly increased hematocrit (Hct) and Hb values, and Hb to RBC distribution width (RDW) ratio, a complementary RBC index for spherocytosis and dense RBCs, when compared with vehicle-treated animals (Figure 2A)