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A novel point mutation in a 3’ splice site of the NADH-cytochrome b5 reductase gene results in immunologically undetectable enzyme and impaired NADH-dependent ascorbate regeneration in cultured fibroblasts of a patient with type II hereditary methemoglobinemia
epigenetics
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DNA fragmentation reduces the genetic integrity of sperm, impairing fertilization and increasing the risk of poor reproductive outcomes, such as miscarriage, failed implantation, and the transmission of genetic defects to offspring