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Similarly, SOD WT misfolds and develops a similar conformation to mutant SOD1, leading to aggregation and the gain of toxic functions in vitro (Bosco et al., 2012

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[DOI] [PubMed] [Google Scholar] 102.Siebenhaar F., Sharov A.A., Peters E.M.J., Sharova T.Y., Syska W., Mardaryev A.N., Freyschmidt-Paul P., Sundberg J.P., Maurer M., Botchkarev V.A