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For instance, the GSH/GPX4 axis serves as a barrier to obstruct ferroptosis, while cys is the inhibitory amino acid in the synthesis of GSH and blockade of cys import via SLC7A11 triggering ferroptosis by decreasing GSH levels (Sun et al., 2018)

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OPN, a multifunctional protein, has important functions, particularly in cardiovascular diseases, kidney stones, and in the process of inflammation, biomineralization, and cell viability [186]