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In hypoxic conditions, HIF-1 acts as the main mediator of a series of in vivo pathophysiological responses, including angiogenesis, cell proliferation, and transcriptional induction of survival genes ( Erythropoietin (EPO) is the first protein that has been identified downstream of HIF-1 to activate erythropoiesis ( Shh signaling pathway The sonic hedgehog (Shh) signaling pathway plays an important role in endogenous neurogenesis ( Notch pathway The Notch signaling pathway is a highly conserved signaling pathway that plays a critical role in the process of endogenous neurogenesis ( PI3K pathway The Phosphatidylinositol-3-kinase (PI3K) pathway has already been identified to play an important role in cell survival of endogenous neurogenesis and many studies have focused on use of the PI3K pathway to treat brain injury after stroke ( Wnt/β-catenin pathway Wingless-type mouse mammary tumor virus integration site/β-catenin (Wnt/β-catenin) signaling is a vital pathway for endogenous neurogenesis and an essential signaling system during embryonic development and aging ( Other influencing factors The process of neurogenesis after HIBD is made up of multiple signaling molecules and pathways that are interconnected, coordinated, and work together to regulate the continuous process of neurogenesis
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C’est pourquoi elles constituent une stratégie valide pour le maintien ou le rechargement en cas de conditions où cette protéine protectrice n’est plus sécrétée, comme dans les gastrectomies, l’achlorhydrie, etc