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In other contexts, however, the accumulation of non-proliferating senescent cells and prolonged SASP exposure have detrimental effects, being associated with chronic inflammation, tissue dysfunction, and active contribution to the ageing process ( As research on cellular senescence progresses, it has become increasingly evident that senescence is not a singular, uniform state but rather encompasses a spectrum of phenotypes and cellular programs
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It has been widely studied in preclinical models for its potential to support tissue regeneration, angiogenesis, and inflammation modulation
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