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With rising concentrations of KA, the K m values of the monophenolase activity increased and the V max values decreased, an indication of a mixed mode of inhibition, with an inhibition constant K I of 1.1 μM and K IS of 61 μM
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Unlike other drug trials, integrative oncology studies encounter additional methodological issues such as the plethora of supplement formulations and their composition, variability in concentration of bioactive compounds across different source materials, patient-driven simultaneous use of products and multifaceted endpoints that include tumour response objective assessments as well as symptom control, quality-of-life evaluation, and biomarker modification (19)