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Determinants of short- and long-term outcomes of an australian cohort of patients admitted with alcoholic hepatitis

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demonstrated that genes such as transforming growth factor beta-induced ( TGFBI ), C-X-C motif chemokine ligand 2 ( CXCL2 ), and solute carrier family 38 member 1 ( SLC38A1 ) are consistently hypermethylated and downregulated in trastuzumab-resistant HER2+ breast cancer, with TGFBI showing the highest silencing at both the mRNA and protein levels [93]