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Other mutations, such as those in Gα protein subunits (such as GNAS ), MYC , TP53 , and PTEN , drive metabolic shifts in PDAC

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In terms of anti-inflammatory pathways and mitigating effects, most of the above metabolites have been shown to have anti-inflammatory effects, with HHC having the strongest anti-inflammatory activity among the diarylheptanes or diarylheptylamine analogs of curcumin 67