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In CFTR KO mice, basal ELF GSH levels are roughly 50% of normal, and the capacity to increase ELF GSH also compromised [20]
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Catalase (CAT) converts peroxisome-derived H 2 O 2 to water and oxygen under physiological conditions ( 2 O 2 ( 2 O 2 may be transformed, along with O2โขโ, into the highly toxic and oxidizing OHโข hydrogen peroxide ( 2 O 2 .MPO uses the H 2 O 2 neutrophil produced to create hypochlorite ions (OCl โ) ( 2 O 2 can freely diffuse across cell membranes and oxidize molecules farther away, such as pathogen membrane lipids
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