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Specifically, in patients with acute cerebral ischemia, heightened peripheral levels of Tie2-expressing macrophages are strongly associated with improved clinical prognoses, implying that targeting these Tie2-high macrophages in the systemic circulation might constitute a pivotal mechanism mediating the brain’s intrinsic neuroprotective response (Sheng et al., 2021)
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The hallmark of PPHN physiology is sustained elevation of pulmonary vascular resistance (PVR) and persistent hypoxemia after birth (2)
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