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4.2 Targeting Gln metabolism to inhibit tumor proliferation 4.2.1 Inhibition of Gln uptake Tumor survival and proliferation are heavily dependent on Gln, a hydrophilic amino acid that must be transported into tumor cells by transmembrane proteins, such as SLC1A5, SLC6A14, and SLC38A1/2

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doi: 10.1136/esmoopen-2020-000724 40 ArcilaMEChaftJENafaKRoy-ChowdhuriSLauCZaidinskiMet al

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