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The optimized oxymatrine microgel cream (OMC) formulation exhibited superior therapeutic outcomes, including restoration of epidermal keratinization patterns, reduction of peripheral leukocytosis, and systemic downregulation of proinflammatory mediators (IL-1β, TNF-α, CXCR3, CXCL10, IL-6, IL-10, IL-17A, IL-31), along with suppression of TRPA1/TRPV1 expression in trigeminal ganglia and cytokine modulation in thymic interferon (IFN)-γ and splenic IL-17A tissues
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