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Research into genetic predisposition has identified genes linked to DR risk, progression, and severity, including those involved in angiogenesis (VEGFA), inflammation (IL-6, TNF-α), oxidative stress (SOD1, SOD2), and glucose metabolism (AKR1B1)

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If results indicate inferior PK properties—such as high clearance, short half-life (t 1/2 ) and/or low bioavailability—PD effects will likely be sub-optimal