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IKK activity is triggered during aging by NF-κB (Kim et al., 2002), which further modulates the p38 MAPK, extracellular signal-regulated kinase (ERK), and c-Jun N-terminal kinases (JNKs) pathways that modulate the NF-κB-dependent transcriptional activity during the inflammatory reaction
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Notably, when administered at a dose of 62.5 mg/kg, NMN produced optimal treatment effects compared to other doses (500, 250, 125, and 31.25 mg/kg), suggesting that high dosage of NMN may introduce adverse effects on post-ischemic neurons
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