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Studies have shown that patients with PD exhibit a reduction in the abundance of several beneficial bacteria, such as the families Prevotellaceae and Lachnospiraceae , and the genera Prevotella (particularly Prevotella copri ), Ruminococcus , Blautia , Dorea , Roseburia , and Faecalibacterium [119]
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prior to the introduction of CRISPR-Cas-9, zinc-finger nucleases (ZFN) were the method of choice to edit DNA, but CRISPR-Cas-9 offers wide advantages, which range from increased efficacy to economization of designs [157]
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