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Funding This work was financially supported by the Marie Skłodowska-Curie COFUND Action (Grant Agreement 101034352 “imπACT”), the Future and Emerging Technologies (Grant Agreement 858014 “PANACHE”) and the Societal Challenges (Grant Agreement 963845 “ONTOX”) sections of the European Horizon2020 framework program, the US Alternatives Research and Development Foundation (Grant 2021), the Research Foundation Flanders (Grant Agreement G070422N), the Methusalem program of the Flemish government (Grant 2020), and the Scientific Fund Willy Gepts (Grant 2021)