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In PD α-synuclein mutations is common and in sporadic PD LBs strongly immunoreactive for wild-type α-synuclein with many other protein in their normal or damaged condition (Spillantini et al., 1998)
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Synthèse des lipides neuronaux et production de neurotransmetteurs : l’augmentation de l’acide méthylmalonique mentionnée précédemment empêche la stabilisation correcte de la myéline, en raison de la formation d’acides gras anormaux, conséquence de la carence en Succinyl-CoA
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