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The receptor normally recognizes endogenous GHRH, and structural work has shown that peptide binding is mediated through coordinated interactions between the ligand, the receptor extracellular domain, and the transmembrane bundle
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It was demonstrated that Nε-Hcy-Lys was elevated in patients with acute myocardial infarction and its level was correlated with plasma asymmetric dimethylarginine, the endogenous inhibitor of endothelial nitric oxide synthase 10,11
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