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Glutathione- S- transferase 5-5 transfected into the bacteria allowed the induction of base-pair mutations on exposure to 1,2-dibromoethane, whereas a 20-fold extracellular excess of the enzyme did not permit 1,2-dibromoethane-induced mutations in non-transfected bacteria in the presence of reduced glutathione (Thier et al., 1993)