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CagriSema (Cagrilintide + Semaglutide): Amylin + GLP-1 Efficacy headline: 20.4% mean weight loss in REDEFINE 1 under intent-to-treat analysis and 22.7% under on-treatment analysis, with weaker efficacy in the type 2 diabetes population of REDEFINE 2

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Elevated levels of NNMT activity is associated with reduced cellular energy expenditure and increased fat storage