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The influence of macronutrient composition of the diet also made a reasonable target of early research as growth retardation was thought to be a key feature of the rodent DR effect

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Large-scale epidemiological studies show that plasma Cys, but not Met, is positively associated with body mass index and fat mass independent of caloric intake and physical activity, thus rendering support to the preclinical studies (Elshorbagy, Kozich, Smith, & Refsum, 2012