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EVs released by Leishmania play a key role in infection and immunomodulation

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There are four broad mechanisms that have been identified for inducing ferroptosis—(1) inhibition of system x c − , (2) inhibition/degradation/inactivation of GPX4, (3) depletion of reduced CoQ 10 , and (4) induction of lipid peroxidation through peroxides, iron, or PUFA overload