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Significant research advancements have led to a better understanding of the effect of “advanced paternal age” (APA) on fertility and offspring health, as well as possible underlying mechanisms

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Moreover, various previous researches support that MeCbl can be used in an off-label manner in addition to its well-established applications in hyperhomocysteinaemia, pernicious anemia, and peripheral neuropathy, with ultra-high dose MeCbl up to 500 mg/day in patients with chronic renal failure and chronic axonal degeneration 42,43