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Peptidergic neurons regulate mast cells through production of substance P, calcitonin gene-related peptide (CGRP), and vasoactive intestinal polypeptide (VIP) [91, 92]

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A recent human study on women with PCOS found that compared with healthy women, the mtDNA content in PCOS patients was significantly reduced, accompanied by more obvious metabolic abnormalities (Rojo et al., 2024)