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Typical features of TME include moderate acidity (pH 6.5–7.0), excessive secretion of reactive oxygen species (such as H 2 O 2 ), and reducing molecules (such as glutathione and GSH) ( 2.3.1 pH-responsive NDDS Even when oxygen is plentiful, tumor cells tend to metabolize glucose through glycolysis rather than efficient oxidative phosphorylation

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doi: 10.1007/s12035-025-05223-7 48