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DISCUSSION Penile length is determined by the tunica albuginea, which is mainly composed by collagen bundles and elastic fibers.15,16 LOX can catalyze the crosslinking of collagen and elastin proteins into insoluble mature fibers.17,18,19 Our results have revealed that both the protein expression and activity of LOX sharply decreased with age to relative stable levels
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When sperm DNA exhibits reduced condensation, chromatin is much more susceptible to OS and deletions, mutations, DNA cross-links, and chromosomal rearrangements [195], and it has been associated with subfertility in several species [196]