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Here are some common symptoms of vitamin B12 deficiency: fatigue and weakness pale skin rapid heartbeat and breathing shortness of breath dizziness or lightheadedness constipation, diarrhea, or other digestive issues loss of appetite and weight loss numbness or tingling in the hands and feet muscle weakness or stiffness difficulty walking or balancing memory loss or cognitive impairment depression, anxiety, irritability, or other mood changes Risk factors for vitamin B12 deficiency There are several risk factors that can contribute to a deficiency in vitamin B12, including: A diet lacking in vitamin B12-rich foods, such as meat, fish, and dairy products