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For example, Wholesome Story’s Myo-Inositol & D-Chiro Inositol + Folate combines MI with D-chiro-inositol (DCI) in a 40:1 ratio, a balance that has been studied specifically in people with PCOS.10 It also includes folate, which is commonly paired with inositol in PCOS research.1 But for broad, evidence-aligned effectiveness — especially for general metabolic support or insulin sensitivity — a straightforward MI supplement at a clinically relevant dose remains the most versatile option, which is why Life Extension earns the edge here